Yes. Hard drives usually come in either 2 mb or 8 mb caches. The drives with larger caches will perform better since they can temporarily store more and larger files in their memory for repeated access. While transfering large files, such as when editing large video files, the cache size will make almost no difference. However, for working with many smaller files, the transfer speed will be greater. It is usually worth the small increase in cost for the significant performance gain you get. If you are trying to save money and don’t care about the performance increase, your best bet is to get a 5400 RPM drive which will run quieter and cooler for cheaper.